Minimizing Steps - Maximizing Efficiency
- Develop Grignard-type reactions in water to minimize protection-deprotection of functional groups such as hydroxyl, carboxylic, and amine groups in synthesis.
- Develop catalytic transformation of naturally abundant C-H and C-OH bonds to replace organic halides (which generate stoichiometric organic halide waste) as the reaction platform for C-C bond formations, generally in water.
- Develop Cross-Dehydrogenative Coupling (CDC) reactions by directly constructing C-C bonds from two different C-H bonds with the generation of H2 or in the presence of oxidant, which eliminates the preparation of functional groups and thus make synthetic schemes shorter and more efficient.
C.-J. Li, Acc. Chem. Res. 2008, 42, 335-344.
C.-J. Li, Angew. Chem. Int. Ed. 2014, 53, 74-100.